Tirzepatide

Research-Grade Peptide

About Tirzepatide

Tirzepatide Research Peptide Tirzepatide is a novel dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist engineered for advanced metabolic research. This first-in-class synthetic peptide has generated substantial interest among researchers for its unique dual-agonist mechanism and potent metabolic effects observed in preclinical models. Tirzepatide is provided exclusively for in vitro and in vivo research purposes and is not intended for human consumption.

Molecular Profile

Amino Acid Count:

39 amino acids

Molecular Weight:

Approximately 4813.45 Da Classification: Dual GIP/GLP-1 receptor agonist; twincretin peptide CAS Number: 2023788-19-2

Molecular Formula:

C225H348N48O68 Sequence Basis: Based on the native GIP(1-42) sequence with modifications to confer GLP-1 receptor cross-reactivity Acylation: Contains a C-20 fatty diacid moiety attached via a linker at lysine-20, facilitating albumin binding and extended half-life Physical

Appearance:

White to off-white lyophilized powder

Mechanism of Action

Tirzepatide functions as a dual incretin receptor agonist, engaging both the GIP receptor and the GLP-1 receptor. The peptide demonstrates imbalanced agonism, exhibiting full agonist activity at the GIP receptor while functioning as a partial agonist at the GLP-1 receptor. Both receptors are members of the class B G-protein coupled receptor (GPCR) family, and their activation stimulates adenylyl cyclase to elevate intracellular cAMP concentrations. At the GIP receptor, tirzepatide promotes glucose-dependent insulin secretion and has been shown in preclinical models to enhance adipocyte lipid storage and improve adipose tissue insulin sensitivity. Concurrent GLP-1 receptor activation contributes complementary effects on glucose homeostasis, including suppression of glucagon secretion from pancreatic alpha cells and modulation of gastric emptying rates in research models. The dual receptor engagement distinguishes tirz