Tesamorelin

Research-Grade Peptide

About Tesamorelin

Tesamorelin Research Peptide Tesamorelin is a synthetic analog of growth hormone-releasing hormone (GHRH) designed for advanced endocrinological and metabolic research applications. This modified peptide incorporates a trans-3-hexenoic acid group at its N-terminus, conferring enhanced stability and bioactivity relative to native GHRH(1-44). Tesamorelin is supplied exclusively for in vitro and in vivo laboratory research and is not intended for human consumption or clinical application.

Molecular Profile

Amino Acid Count:

44 amino acids (modified GHRH analog)

Molecular Weight:

Approximately 5135.93 Da Classification: Growth hormone-releasing hormone (GHRH) analog; growth hormone secretagogue CAS Number: 218949-48-5 Modification: Trans-3-hexenoic acid conjugated to the N-terminal tyrosine residue Physical

Appearance:

White to off-white lyophilized powder

Solubility:

Soluble in sterile water and dilute acidic aqueous solutions

Mechanism of Action

Tesamorelin acts as a specific agonist of the GHRH receptor (GHRHR), a class B G-protein coupled receptor expressed predominantly on somatotroph cells of the anterior pituitary gland. Upon binding, tesamorelin activates the Gs-alpha subunit, stimulating adenylyl cyclase and elevating intracellular cAMP levels. This signaling cascade activates protein kinase A (PKA), which in turn promotes the transcription of the growth hormone (GH) gene and stimulates the exocytosis of GH-containing secretory granules. The N-terminal trans-3-hexenoic acid modification protects tesamorelin from aminopeptidase-mediated degradation, a primary route of inactivation for native GHRH. This structural enhancement results in improved metabolic stability while preserving full receptor agonist activity. In preclinical models, tesamorelin administration has been shown to produce pulsatile GH release that maintains the physiological secretory pattern, in contrast to exogenous GH administration which bypasses the hypothalamic-pituitary feedback axis. Dow