Retatrutide

Research-Grade Peptide

About Retatrutide

Retatrutide Research Peptide Retatrutide (LY3437943) is a novel triple-agonist peptide that activates the glucagon receptor (GCGR), the glucose-dependent insulinotropic polypeptide receptor (GIPR), and the glucagon-like peptide-1 receptor (GLP-1R). As the first triple-incretin receptor agonist to enter advanced preclinical and research investigation, retatrutide represents a cutting-edge tool for studying multi-receptor metabolic signaling. This compound is supplied strictly for research use only and is not intended for human consumption.

Molecular Profile

Molecular Weight:

Approximately 4562 Da Classification: Triple GIP/GLP-1/glucagon receptor agonist (triagonist) Development Code: LY3437943 CAS Number: 2381089-83-2 Acylation: Contains a C-20 fatty diacid modification to facilitate albumin binding and extended pharmacokinetic duration Receptor Selectivity: Full agonist at GIPR; partial agonist at GLP-1R and GCGR with balanced activity ratios optimized for multi-target engagement Physical

Appearance:

White to off-white lyophilized powder

Mechanism of Action

Retatrutide engages three distinct class B G-protein coupled receptors simultaneously, each contributing complementary metabolic effects that have been characterized in preclinical research models. This triple-receptor activation profile distinguishes retatrutide from both single-agonist (GLP-1 only) and dual-agonist (GIP/GLP-1) peptides. GLP-1 Receptor Activation: Stimulation of the GLP-1 receptor elevates intracellular cAMP in pancreatic beta cells, augmenting glucose-dependent insulin secretion. In central nervous system models, GLP-1R activation modulates hypothalamic appetite circuits, including effects on POMC-expressing neurons and melanocortin signaling pathways. GIP Receptor Activation: GIPR engagement has been shown in preclinical research to potentiate insulin secretion in a glucose-dependent manner and to modulate adipose tissue function, including effects on lipid storage, adipokine release, and i